genome stability การใช้

• Furthermore, H2A . Z has roles in chromatin for genome stability.
• This gene encodes a protein that is an important regulator of genome stability.
• When functioning normally, the WRN gene and associated protein are important for maintaining genome stability.
• PCNA is critical for DNA replication, and is an essential factor in protecting genome stability.
• This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
• DNA methylation modifies the information passed on by the parent to the progeny, it enables key imprinting and genome stability.
• WRN is important to genome stability, and cells with mutations to WRN are more susceptible to DNA damage and DNA breaks.
• BRCA1 interacts with VCP . BRCA1 also interacts with c-Myc, and other proteins that are critical to maintain genome stability.
• Many studies in model organisms have established the significance of telomere structure and function in regulating genome stability, cellular aging, and oncogenesis.
• Problems with this system can have a large impact on genome stability, and can lead to the formation of tumours or other genetic diseases.
• Among Boulton's achievements is the discovery that the gene RTEL1 serves as an anti-recombinase that affects genome stability and cancer and counteracts toxic recombination.
• The FANCM helicase is required for genome stability in humans and yeast, and is a major factor limiting meiotic CO formation in " A . thaliana ".
• Dudley Goodhead, director of the Medical Research Council's Radiation and Genome Stability Unit in Harwell, Oxfordshire, says it is essential that the criteria for including cases are precise.
• The Bloom syndrome protein interacts with other proteins, such as topoisomerase III? and RMI2, and suppresses illegitimate recombination events between sequences that are divergent from strict homology, thus maintaining genome stability.
• As it is now clear that recombinational repair plays a critical role in the maintenance of genome stability and cancer avoidance, West s work is significant in terms of understanding the molecular basis of human disease.
• A team from the Medical Research Council's Radiation and Genome Stability Unit in Harwell in Oxfordshire and Mount Vernon Hospital in London has just revealed how a single alpha particle can damage human white blood cells.
• 2 ) Donley, N; Thayer MJ ( Apr 2013 ) . " DNA replication timing, genome stability and cancer : late and / or delayed DNA replication timing is associated with increased genomic instability ".
• In this context, synteny was also essential in identifying a highly important region in wheat, the Ph1 locus involved in genome stability and fertility, which was located using information from syntenic regions in rice and Brachypodium.
• "' Karel Riha-Telomeres and genome stability "'- Chromosome integrity and the proper partitioning of the genome to daughter cells are essential prerequisites for the stable inheritance of genetic information over multiple cell divisions.
• They also contain a unique family of repetitive extragenic palindromes called PhREPS whose role is unknown though it is theorised that the stem loop structures the PhREPS are capable of forming may play a role in transcription termination or genome stability.